Current evidence for COPD management with dual long-acting muscarinic antagonist/long-acting β2-agonist bronchodilators
نویسندگان
چکیده
منابع مشابه
Long-term Safety and Efficacy of Indacaterol, a Long-Acting β2-Agonist, in Subjects With COPD
a From the Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, ON, Canada b Department of Medicine, University of Toronto, Toronto, ON, Canada c Department of Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE d Novartis Horsham Research Centre, Horsham, West Sussex, England e Novartis Pharmaceuticals, East H...
متن کاملEfficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis.
BACKGROUND The place of long-acting β agonist/long-acting muscarinic antagonist (LABA/LAMA) combinations in stable patients with COPD is not well defined. The purpose of this study was to systematically review the efficacy and safety of LABA/LAMA combinations. METHODS Several databases and manufacturers' websites were searched for relevant clinical trials. Randomised control trials, at least ...
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BACKGROUND AND PURPOSE β2 -adrenoceptor agonists are widely used in the management of obstructive airway diseases. Besides their bronchodilatory effect, several studies suggest inhibitory effects on various aspects of inflammation. The aim of our study was to determine the efficacy of the long-acting β2 -adrenoceptor agonist olodaterol to inhibit pulmonary inflammation and to elucidate mechanis...
متن کاملThe role of long-acting bronchodilators in the management of stable COPD.
Bronchodilators form the foundation of symptomatic treatment of COPD. Several long-acting bronchodilators are now available for use in COPD, but publications of large-scale studies of their efficacy have, for the most part, postdated the publication of major clinical guidelines. This article provides a critical review of large (> or =50 patients), double-blind, clinical trials of three long-act...
متن کاملβ2-Adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting β2-agonist therapy
The aim of the present study was to investigate bronchoprotective sensitivity in patients receiving regular treatment with shortand long-acting β2-agonists and to evaluate any possible association with genetic polymorphism. Thirty-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to re...
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ژورنال
عنوان ژورنال: Postgraduate Medicine
سال: 2020
ISSN: 0032-5481,1941-9260
DOI: 10.1080/00325481.2019.1702834